ball milling parameters on solubility
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ball milling parameters on solubility

The Effect of Milling Time and Speed on Solid Solubility ...

2021-3-24  The effect of milling time and speed on solid solubility of V in Al and grain refinement was studied. High-energy ball milling was used to produce Al-xV (x = 2, 5, and 10 at.%) alloys at milling speeds of 280 and 350 RPM. The ball-milling time was varied from 10 to 100 hours. The ball-milled alloys were consolidated under uniaxial pressure of 3GPa at room temperature.

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Preparation and solid-state characterization of ball ...

The aim of this study was to characterize the effects of high-energy ball milling on saquinavir solid-state characteristics and aqueous solubility for the design of effective buccal drug delivery ...

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The Effect of Milling Time and Speed on Solid Solubility ...

The effect of milling time and speed on solid solubility of V in Al and grain refinement was studied. High-energy ball milling was used to produce Al-xV (x = 2, 5, and 10 at.%) alloys at milling ...

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Overview of milling techniques for improving the ...

2015-7-1  The use of ball milling as a micronization technique for enhancing drug solubility is well supported by literature dating as far back as the 1970s. Apart from its comminution function, ball milling also serves as an intensive mixing technique capable of producing co-ground drug-excipient mixtures comprising amorphous drug forms intimately mixed ...

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Study of the process of stirred ball milling of poorly ...

2010-2-20  The objective of this work was to investigate the mechanism of very fine grinding in a wet ball mill as a function of process parameters, i.e. rotation speed of the mill and grinding medium bead size. The ball mill used was a Dynomill and the grinding medium consisted of zirconium oxide beads. The product is a poorly water-soluble organic compound.

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(PDF) Overview of milling techniques for improving the ...

2015-2-17  Both fluid energy and ball milling techniques involve size. reduction of drug particles in their dry state. The extent of size. reduction achievable in these

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Effect of Cr to Fe onthe Solid Solubility, Lattice ...

2016-8-3  the ball milling effective to develop solid solubil ity of Cr to Fe powder because the high energy kinetics and the balls slugging the sample powder d uring ball milling process.The solid solubility when ball milling process is increased because the

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Ball-milling treatment effect on physicochemical ...

2008-1-1  The ball-milling treatment in this study was achieved with a customized stirring mill driven by a commercially available drill press equipped with a variable speed motor ().The motor turned a shaft that was fitted with four paddles for mixing starch (acquired from Mingyang Biological Inc. Ltd., Guangxi, China) and 6-mm mill balls inside a stainless 1200. ml steel

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Study of processing parameters affecting dissolution ...

2019-7-9  different parameters: milling time (2/10 min), pre lubrication mixing time (5/10 min), lubrication time (1/5 min), compression speed (10/30 rpm), temperature (25°C/37°C), stirrer rpm (50/100 rpm) and stirrer alignment (50/100 mm) were used at two different levels to select three most critical parameters which affect the dissolution profile of

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Nanotechnology from particle size reduction to enhancing ...

2016-1-1  An example of nanonization technique by using ball milling was illustrated by Tanaka (2012), who tried to enhance the solubility of probucol, a poorly water-soluble drug, using a wet milling process with different dispersing agents such as gelucire 44/14 and vitamin E-TPGS. The drug dissolution rate was compared with that of bulk powder.

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Solubility parameters for some reported carbon materials ...

Exfoliation rates in planetary ball mills can be improved when combining the milling with sonication [57] or when designed molecules are added, for

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Preparation and solid-state characterization of ball ...

The aim of this study was to characterize the effects of high-energy ball milling on saquinavir solid-state characteristics and aqueous solubility for the design of effective buccal drug delivery ...

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Effect of ball milling on the physicochemical properties ...

2016-10-26  However, the K a also increased with milling time increased, it showed a maximum at 2.7 × 10 −3 /s at 30-min milling, and then it decreased to 1.56 × 10 −3 /s by 60-min milling. The higher solubility than that of the intact crystal was due to the involvement of

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Overview of milling techniques for improving the ...

2015-7-1  The use of ball milling as a micronization technique for enhancing drug solubility is well supported by literature dating as far back as the 1970s. Apart from its comminution function, ball milling also serves as an intensive mixing technique capable of producing co-ground drug-excipient mixtures comprising amorphous drug forms intimately mixed ...

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A comparative analysis of solubility, segregation, and ...

The parameters used were as follows: stainless steel ball milling media in a 32:1 stainless steel ball-to-powder weight ratio, 180 rpm impeller speed, 12 h milling time,

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EFFECT OF GRINDING SPEED TO PHYSICOCHEMICAL

2020-11-27  There was an increase in the solubility and dissolution rate of Nimesulide and resulted in a reduction in particle size so as to increase the surface area. Between the 2 polymers used, both of them can help to increase the solubility of Nimesulide by using ball milling. The size of the milled particles decreases with increasing polymer weight and

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Ball-milling treatment effect on physicochemical ...

2008-1-1  The ball-milling treatment in this study was achieved with a customized stirring mill driven by a commercially available drill press equipped with a variable speed motor ().The motor turned a shaft that was fitted with four paddles for mixing starch (acquired from Mingyang Biological Inc. Ltd., Guangxi, China) and 6-mm mill balls inside a stainless 1200. ml steel

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Effect of Milling Parameters and Cr Content on

2013-12-11  The steel vial of the ball mill had 250 ml capacity. 21.858 g of powders were put into the container and equal number of steel balls of 1 and 2 cm in diameters were added. Different ball sizes improve accident collisions during milling operation , and minimize the surface layers on the balls and also provide maximum impact energy .

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BJOC - Influence of the milling parameters on the ...

2017-9-7  We previously reported a successful scale-up monoazidation reaction of Ts-β-CD (the reaction scale was 6.5 g, 5 mmol) in a ball-mill (Supporting Information File 1, Table S1, entries 1–4).Considering that the preparation of Ts-β-CD is laborious , its commercial availability is restricted by high costs and limited number of producers, the systematic investigation on the

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Influence of the milling parameters on the nucleophilic ...

2017-9-7  in a ball-mill (Supporting Information File€1, Table S1, entries 1–4). Considering that the preparation of Ts-β-CD is laborious [24,25], its commercial availability is restricted by high costs and limited number of producers, the systematic investigation on the influence of the milling parameters on the reaction

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Effect of ball milling on the physicochemical properties ...

2016-10-26  However, the K a also increased with milling time increased, it showed a maximum at 2.7 × 10 −3 /s at 30-min milling, and then it decreased to 1.56 × 10 −3 /s by 60-min milling. The higher solubility than that of the intact crystal was due to the involvement of

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[PDF] Effect of Cr to Fe on the Solid Solubility, Lattice ...

-Fe-Cr phase was investigated using formula Fe80Cr20. Ball milling process and ultrasonic technique is successfully done to develop solid solubility and improve homogenous, respectively. However, the effect of the Cr to Fe powder is not complete investigated using combination of its process. Ball milling is conducted by milling time of 60 hours and ultrasonic technique were

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Enhancement of Solubility of Nimesulide in the Presence

2013-9-6  solubility of the pure drug and its physical dispersions. Using ball milling technique the physical dispersions of Nimesulide with the polymers, prepared in the ratios of 1:1, 1:3, 1:5 were subjected to size reduction for two different time intervals of 30 min and 90 min,

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The Influence of Milling on the Dissolution Performance of ...

2010-12-17  Optimal milling parameters for simvastatin were found to be at high and middle milling frequencies and middle milling times. In this experimental space, the local optimum according to the model could be found at a milling frequency

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EFFECT OF GRINDING SPEED TO PHYSICOCHEMICAL

2020-11-27  There was an increase in the solubility and dissolution rate of Nimesulide and resulted in a reduction in particle size so as to increase the surface area. Between the 2 polymers used, both of them can help to increase the solubility of Nimesulide by using ball milling. The size of the milled particles decreases with increasing polymer weight and

Read More
Effect of Cr to Fe onthe Solid Solubility, Lattice ...

2016-8-3  the ball milling effective to develop solid solubil ity of Cr to Fe powder because the high energy kinetics and the balls slugging the sample powder d uring ball milling process.The solid solubility when ball milling process is increased because the

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The Scalability of Wet Ball Milling for The Production of ...

2020-5-31  Background: Miniaturization of nanosuspensions preparation is a necessity in order to enable proper formulation screening before nanosizing can be...

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Effects of ball milling treatment on physicochemical ...

2018-7-16  The oyster protein was ball milling treated in this work, and the effects on particle size, conformation, physicochemical properties, and in vitro protein digestibility (IVPD) were investigated. After ball milling treatment, the particle size obviously decreased, and the protein powder became denser and more homogeneous.

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Solubility and dissolution rate enhancement of ibuprofen

In the first-part, two excipients (HPMC and soluplus) were selected from seven, and the optimal ball-milling parameters of speed and time (18 Hz, 15 min) determined based on solubility-enhancement and flow-ability criteria.

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Effect of Milling Parameters on the Structural ...

Al2O3-TiO2-graphite nanocomposite can be used as alternative material for coating application. Fine composite coating particles is commonly produced by milling in a high energy ball milling. This study focused on evaluate the effects on the structural, microstructural and physical properties of Al2O3-TiO2-graphite nanocomposite. The alumina, titania and graphite powder

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