2021-3-24 The effect of milling time and speed on solid solubility of V in Al and grain refinement was studied. High-energy ball milling was used to produce Al-xV (x = 2, 5, and 10 at.%) alloys at milling speeds of 280 and 350 RPM. The ball-milling time was varied from 10 to 100 hours. The ball-milled alloys were consolidated under uniaxial pressure of 3GPa at room temperature.
Read MoreThe aim of this study was to characterize the effects of high-energy ball milling on saquinavir solid-state characteristics and aqueous solubility for the design of effective buccal drug delivery ...
Read MoreThe effect of milling time and speed on solid solubility of V in Al and grain refinement was studied. High-energy ball milling was used to produce Al-xV (x = 2, 5, and 10 at.%) alloys at milling ...
Read More2015-7-1 The use of ball milling as a micronization technique for enhancing drug solubility is well supported by literature dating as far back as the 1970s. Apart from its comminution function, ball milling also serves as an intensive mixing technique capable of producing co-ground drug-excipient mixtures comprising amorphous drug forms intimately mixed ...
Read More2010-2-20 The objective of this work was to investigate the mechanism of very fine grinding in a wet ball mill as a function of process parameters, i.e. rotation speed of the mill and grinding medium bead size. The ball mill used was a Dynomill and the grinding medium consisted of zirconium oxide beads. The product is a poorly water-soluble organic compound.
Read More2015-2-17 Both fluid energy and ball milling techniques involve size. reduction of drug particles in their dry state. The extent of size. reduction achievable in these
Read More2016-8-3 the ball milling effective to develop solid solubil ity of Cr to Fe powder because the high energy kinetics and the balls slugging the sample powder d uring ball milling process.The solid solubility when ball milling process is increased because the
Read More2008-1-1 The ball-milling treatment in this study was achieved with a customized stirring mill driven by a commercially available drill press equipped with a variable speed motor ().The motor turned a shaft that was fitted with four paddles for mixing starch (acquired from Mingyang Biological Inc. Ltd., Guangxi, China) and 6-mm mill balls inside a stainless 1200. ml steel
Read More2019-7-9 different parameters: milling time (2/10 min), pre lubrication mixing time (5/10 min), lubrication time (1/5 min), compression speed (10/30 rpm), temperature (25°C/37°C), stirrer rpm (50/100 rpm) and stirrer alignment (50/100 mm) were used at two different levels to select three most critical parameters which affect the dissolution profile of
Read More2016-1-1 An example of nanonization technique by using ball milling was illustrated by Tanaka (2012), who tried to enhance the solubility of probucol, a poorly water-soluble drug, using a wet milling process with different dispersing agents such as gelucire 44/14 and vitamin E-TPGS. The drug dissolution rate was compared with that of bulk powder.
Read MoreExfoliation rates in planetary ball mills can be improved when combining the milling with sonication [57] or when designed molecules are added, for
Read MoreThe aim of this study was to characterize the effects of high-energy ball milling on saquinavir solid-state characteristics and aqueous solubility for the design of effective buccal drug delivery ...
Read More2016-10-26 However, the K a also increased with milling time increased, it showed a maximum at 2.7 × 10 −3 /s at 30-min milling, and then it decreased to 1.56 × 10 −3 /s by 60-min milling. The higher solubility than that of the intact crystal was due to the involvement of
Read More2015-7-1 The use of ball milling as a micronization technique for enhancing drug solubility is well supported by literature dating as far back as the 1970s. Apart from its comminution function, ball milling also serves as an intensive mixing technique capable of producing co-ground drug-excipient mixtures comprising amorphous drug forms intimately mixed ...
Read MoreThe parameters used were as follows: stainless steel ball milling media in a 32:1 stainless steel ball-to-powder weight ratio, 180 rpm impeller speed, 12 h milling time,
Read More2020-11-27 There was an increase in the solubility and dissolution rate of Nimesulide and resulted in a reduction in particle size so as to increase the surface area. Between the 2 polymers used, both of them can help to increase the solubility of Nimesulide by using ball milling. The size of the milled particles decreases with increasing polymer weight and
Read More2008-1-1 The ball-milling treatment in this study was achieved with a customized stirring mill driven by a commercially available drill press equipped with a variable speed motor ().The motor turned a shaft that was fitted with four paddles for mixing starch (acquired from Mingyang Biological Inc. Ltd., Guangxi, China) and 6-mm mill balls inside a stainless 1200. ml steel
Read More2013-12-11 The steel vial of the ball mill had 250 ml capacity. 21.858 g of powders were put into the container and equal number of steel balls of 1 and 2 cm in diameters were added. Different ball sizes improve accident collisions during milling operation , and minimize the surface layers on the balls and also provide maximum impact energy .
Read More2017-9-7 We previously reported a successful scale-up monoazidation reaction of Ts-β-CD (the reaction scale was 6.5 g, 5 mmol) in a ball-mill (Supporting Information File 1, Table S1, entries 1–4).Considering that the preparation of Ts-β-CD is laborious , its commercial availability is restricted by high costs and limited number of producers, the systematic investigation on the
Read More2017-9-7 in a ball-mill (Supporting Information File€1, Table S1, entries 1–4). Considering that the preparation of Ts-β-CD is laborious [24,25], its commercial availability is restricted by high costs and limited number of producers, the systematic investigation on the influence of the milling parameters on the reaction
Read More2016-10-26 However, the K a also increased with milling time increased, it showed a maximum at 2.7 × 10 −3 /s at 30-min milling, and then it decreased to 1.56 × 10 −3 /s by 60-min milling. The higher solubility than that of the intact crystal was due to the involvement of
Read More-Fe-Cr phase was investigated using formula Fe80Cr20. Ball milling process and ultrasonic technique is successfully done to develop solid solubility and improve homogenous, respectively. However, the effect of the Cr to Fe powder is not complete investigated using combination of its process. Ball milling is conducted by milling time of 60 hours and ultrasonic technique were
Read More2013-9-6 solubility of the pure drug and its physical dispersions. Using ball milling technique the physical dispersions of Nimesulide with the polymers, prepared in the ratios of 1:1, 1:3, 1:5 were subjected to size reduction for two different time intervals of 30 min and 90 min,
Read More2010-12-17 Optimal milling parameters for simvastatin were found to be at high and middle milling frequencies and middle milling times. In this experimental space, the local optimum according to the model could be found at a milling frequency
Read More2020-11-27 There was an increase in the solubility and dissolution rate of Nimesulide and resulted in a reduction in particle size so as to increase the surface area. Between the 2 polymers used, both of them can help to increase the solubility of Nimesulide by using ball milling. The size of the milled particles decreases with increasing polymer weight and
Read More2016-8-3 the ball milling effective to develop solid solubil ity of Cr to Fe powder because the high energy kinetics and the balls slugging the sample powder d uring ball milling process.The solid solubility when ball milling process is increased because the
Read More2020-5-31 Background: Miniaturization of nanosuspensions preparation is a necessity in order to enable proper formulation screening before nanosizing can be...
Read More2018-7-16 The oyster protein was ball milling treated in this work, and the effects on particle size, conformation, physicochemical properties, and in vitro protein digestibility (IVPD) were investigated. After ball milling treatment, the particle size obviously decreased, and the protein powder became denser and more homogeneous.
Read MoreIn the first-part, two excipients (HPMC and soluplus) were selected from seven, and the optimal ball-milling parameters of speed and time (18 Hz, 15 min) determined based on solubility-enhancement and flow-ability criteria.
Read MoreAl2O3-TiO2-graphite nanocomposite can be used as alternative material for coating application. Fine composite coating particles is commonly produced by milling in a high energy ball milling. This study focused on evaluate the effects on the structural, microstructural and physical properties of Al2O3-TiO2-graphite nanocomposite. The alumina, titania and graphite powder
Read More